InnateDB Protein
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IDBP-184584.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Slc38a7
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Protein Name
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solute carrier family 38, member 7
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000037023
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InnateDB Gene
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IDBG-184582 (Slc38a7)
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Protein Structure
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Function |
Mediates sodium-dependent transport of amino acids. Substrate preference is ranked l-glutamine > l-histidine > l- serine > l-alanine > l-aspargine > l-aspartic acid > l-glutamic acid > l-methionine > l-leucine > l-glycine. {ECO:0000269PubMed:21511949}.
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Subcellular Localization |
Membrane {ECO:0000269PubMed:21511949}; Multi-pass membrane protein {ECO:0000269PubMed:21511949}. Note=In neurons, located in soma and axons.
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Disease Associations |
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Tissue Specificity |
Highly expressed in the brain, including the hippocampus, especially in the granular layer of dentate gyrus cells and the pyramidal cell layer of the hippocampus, amygdala, thalamus, hypothalamus, in the layer of Purkinje cells in the cerebellum and the layers of cortex. Particularly strong expression in neurons of the ventromedial hypothalamus, basolateral amygdala, ventral tegmental area, and locus coeruleus. Not detected in glial cells, including astrocytes. In addition to brain, also expressed in the spinal cord (at protein level). {ECO:0000269PubMed:21511949}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0005290
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L-histidine transmembrane transporter activity
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GO:0005313
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L-glutamate transmembrane transporter activity
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GO:0015179
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L-amino acid transmembrane transporter activity
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GO:0015180
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L-alanine transmembrane transporter activity
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GO:0015182
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L-asparagine transmembrane transporter activity
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GO:0015183
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L-aspartate transmembrane transporter activity
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GO:0015186
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L-glutamine transmembrane transporter activity
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GO:0015190
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L-leucine transmembrane transporter activity
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GO:0015191
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L-methionine transmembrane transporter activity
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GO:0015194
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L-serine transmembrane transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2679005
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InterPro |
IPR013057
Amino acid transporter, transmembrane
IPR018227
Tryptophan/tyrosine permease
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PFAM |
PF01490
PF03222
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BWH0
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PhosphoSite |
PhosphoSite-Q8BWH0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
234595
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UniGene |
Mm.29267
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RefSeq |
NP_766346
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MGI ID |
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MGI Symbol |
Slc38a7
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OMIM |
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CCDS |
CCDS22567
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HPRD |
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IMGT |
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EMBL |
AK052548
AK171137
BC031853
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GenPept |
AAH31853
BAC35035
BAE42270
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