Version 5.4
Mus musculus Protein: Iqsec3
Summary
InnateDB Protein IDBP-184629.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Iqsec3
Protein Name IQ motif and Sec7 domain 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000038653
InnateDB Gene IDBG-184627 (Iqsec3)
Protein Structure
UniProt Annotation
Function Acts as a guanine nucleotide exchange factor (GEF) for ARF1. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed specifically in the adult brain, but not in the fetal brain at 14 dpc. {ECO:0000269PubMed:17981261}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0030036 actin cytoskeleton organization
GO:0032012 regulation of ARF protein signal transduction
GO:0043087 regulation of GTPase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030054 cell junction
GO:0045211 postsynaptic membrane
GO:0060077 inhibitory synapse
Protein Structure and Domains
PDB ID MGI:2677208
InterPro IPR000048 IQ motif, EF-hand binding site
IPR000904 Sec7 domain
PFAM PF00612
PF01369
PRINTS
PIRSF
SMART SM00015
SM00222
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3TES0
PhosphoSite PhosphoSite-Q3TES0
TrEMBL
UniProt Splice Variant
Entrez Gene 243621
UniGene Mm.420488
RefSeq NP_001028526
MGI ID
MGI Symbol Iqsec3
OMIM
CCDS CCDS20491
HPRD
IMGT
EMBL AK122446 AK147268 AK169437
GenPept BAC65728 BAE27809 BAE41178

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca