InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Got2

Summary

InnateDB Protein

IDBP-184634.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Got2

Protein Name

glutamate oxaloacetate transaminase 2, mitochondrial

Synonyms

AL022787; FABP-pm; Got-2; mAspAT;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034097

InnateDB Gene

IDBG-184632 (Got2)

Protein Structure

UniProt Annotation

Function

Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269PubMed:20977429, ECO:0000269PubMed:7878064}.

Subcellular Localization

Mitochondrion matrix. Cell membrane.

Disease Associations

Tissue Specificity

Detected in brain (at protein level). {ECO:0000269PubMed:17442055}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity
GO:0016212	kynurenine-oxoglutarate transaminase activity
GO:0030170	pyridoxal phosphate binding
GO:0044822	poly(A) RNA binding
GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity

Biological Process

GO:0006103	2-oxoglutarate metabolic process
GO:0006107	oxaloacetate metabolic process
GO:0006531	aspartate metabolic process
GO:0006532	aspartate biosynthetic process
GO:0006533	aspartate catabolic process
GO:0006536	glutamate metabolic process
GO:0009058	biosynthetic process
GO:0015908	fatty acid transport
GO:0019550	glutamate catabolic process to aspartate
GO:0019551	glutamate catabolic process to 2-oxoglutarate
GO:0045471	response to ethanol
GO:0097052	L-kynurenine metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome