InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fgf10

Summary

InnateDB Protein

IDBP-184668.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fgf10

Protein Name

fibroblast growth factor 10

Synonyms

AEY17; BB213776; Fgf-10; Gsfaey17;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022246

InnateDB Gene

IDBG-184666 (Fgf10)

Protein Structure

UniProt Annotation

Function

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed abundantly in embryos and the lung, and at much lower levels in brain and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	1 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005111	type 2 fibroblast growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding
GO:0042056	chemoattractant activity

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0000187	activation of MAPK activity
GO:0001525	angiogenesis
GO:0001656	metanephros development
GO:0001759	organ induction
GO:0001823	mesonephros development
GO:0001974	blood vessel remodeling
GO:0003338	metanephros morphogenesis
GO:0006935	chemotaxis
GO:0007267	cell-cell signaling
GO:0007368	determination of left/right symmetry
GO:0007431	salivary gland development
GO:0007435	salivary gland morphogenesis
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008544	epidermis development
GO:0008589	regulation of smoothened signaling pathway
GO:0009880	embryonic pattern specification
GO:0009887	organ morphogenesis
GO:0010468	regulation of gene expression
GO:0010631	epithelial cell migration
GO:0010634	positive regulation of epithelial cell migration
GO:0010838	positive regulation of keratinocyte proliferation
GO:0014070	response to organic cyclic compound
GO:0021983	pituitary gland development
GO:0030154	cell differentiation
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030324	lung development
GO:0030538	embryonic genitalia morphogenesis
GO:0030855	epithelial cell differentiation
GO:0030878	thyroid gland development
GO:0030916	otic vesicle formation
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031016	pancreas development
GO:0031069	hair follicle morphogenesis
GO:0031076	embryonic camera-type eye development
GO:0031532	actin cytoskeleton reorganization
GO:0031659	positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0032355	response to estradiol
GO:0032496	response to lipopolysaccharide
GO:0032781	positive regulation of ATPase activity
GO:0032808	lacrimal gland development
GO:0032925	regulation of activin receptor signaling pathway
GO:0034394	protein localization to cell surface
GO:0035019	somatic stem cell maintenance
GO:0035108	limb morphogenesis
GO:0035265	organ growth
GO:0042060	wound healing
GO:0042246	tissue regeneration
GO:0042472	inner ear morphogenesis
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042693	muscle cell fate commitment
GO:0043410	positive regulation of MAPK cascade
GO:0043616	keratinocyte proliferation
GO:0045596	negative regulation of cell differentiation
GO:0045739	positive regulation of DNA repair
GO:0045740	positive regulation of DNA replication
GO:0045747	positive regulation of Notch signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045931	positive regulation of mitotic cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046579	positive regulation of Ras protein signal transduction
GO:0046877	regulation of saliva secretion
GO:0048146	positive regulation of fibroblast proliferation
GO:0048286	lung alveolus development
GO:0048514	blood vessel morphogenesis
GO:0048536	spleen development
GO:0048538	thymus development
GO:0048557	embryonic digestive tract morphogenesis
GO:0048565	digestive tract development
GO:0048566	embryonic digestive tract development
GO:0048645	organ formation
GO:0048730	epidermis morphogenesis
GO:0048752	semicircular canal morphogenesis
GO:0048754	branching morphogenesis of an epithelial tube
GO:0048807	female genitalia morphogenesis
GO:0048808	male genitalia morphogenesis
GO:0050671	positive regulation of lymphocyte proliferation
GO:0050673	epithelial cell proliferation
GO:0050674	urothelial cell proliferation
GO:0050677	positive regulation of urothelial cell proliferation
GO:0050678	regulation of epithelial cell proliferation
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050872	white fat cell differentiation
GO:0050918	positive chemotaxis
GO:0050930	induction of positive chemotaxis
GO:0051145	smooth muscle cell differentiation
GO:0051549	positive regulation of keratinocyte migration
GO:0060019	radial glial cell differentiation
GO:0060173	limb development
GO:0060174	limb bud formation
GO:0060425	lung morphogenesis
GO:0060428	lung epithelium development
GO:0060430	lung saccule development
GO:0060436	bronchiole morphogenesis
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0060445	branching involved in salivary gland morphogenesis
GO:0060447	bud outgrowth involved in lung branching
GO:0060449	bud elongation involved in lung branching
GO:0060496	mesenchymal-epithelial cell signaling involved in lung development
GO:0060510	Type II pneumocyte differentiation
GO:0060513	prostatic bud formation
GO:0060541	respiratory system development
GO:0060594	mammary gland specification
GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0060615	mammary gland bud formation
GO:0060661	submandibular salivary gland formation
GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0060667	branch elongation involved in salivary gland morphogenesis
GO:0060879	semicircular canal fusion
GO:0060915	mesenchymal cell differentiation involved in lung development
GO:0061033	secretion by lung epithelial cell involved in lung growth
GO:0061115	lung proximal/distal axis specification
GO:0070075	tear secretion
GO:0070352	positive regulation of white fat cell proliferation
GO:0070371	ERK1 and ERK2 cascade
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070384	Harderian gland development
GO:0071157	negative regulation of cell cycle arrest
GO:0071338	positive regulation of hair follicle cell proliferation
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand