InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbxl3

Summary

InnateDB Protein

IDBP-184719.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxl3

Protein Name

F-box and leucine-rich repeat protein 3

Synonyms

AU041772; AW212966; FBK; Fbl3a; Fbxl3a; Ovtm; Play68;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022720

InnateDB Gene

IDBG-184717 (Fbxl3)

Protein Structure

UniProt Annotation

Function

Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex. {ECO:0000269PubMed:17462724, ECO:0000269PubMed:17463252, ECO:0000269PubMed:18953409, ECO:0000269PubMed:23452855, ECO:0000269PubMed:23452856, ECO:0000269PubMed:23616524}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Predominantly nuclear.

Disease Associations

Tissue Specificity

Ubiquitously expressed but enriched in brain. Diffusely expressed in the suprachiasmatic nucleus, SCN. {ECO:0000269PubMed:17462724, ECO:0000269PubMed:18953409}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031648	protein destabilization
GO:0042752	regulation of circadian rhythm
GO:0043153	entrainment of circadian clock by photoperiod
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0048511	rhythmic process