InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pir

Summary

InnateDB Protein

IDBP-184739.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pir

Protein Name

pirin

Synonyms

2310042L19Rik; Pirnl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033749

InnateDB Gene

IDBG-184737 (Pir)

Protein Structure

UniProt Annotation

Function

Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro) (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly localized in dot-like subnuclear structures. {ECO:0000250}.

Disease Associations

Tissue Specificity

Weakly expressed in bone marrow. {ECO:0000269PubMed:20010624}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0005515	protein binding
GO:0008127	quercetin 2,3-dioxygenase activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030099	myeloid cell differentiation
GO:0030224	monocyte differentiation
GO:0055114	oxidation-reduction process
GO:2001141	regulation of RNA biosynthetic process