InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pam

Summary

InnateDB Protein

IDBP-184782.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Pam

Protein Name

peptidylglycine alpha-amidating monooxygenase

Synonyms

PHM;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095228

InnateDB Gene

IDBG-184778 (Pam)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004497	monooxygenase activity
GO:0004504	peptidylglycine monooxygenase activity
GO:0004598	peptidylamidoglycolate lyase activity
GO:0005507	copper ion binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
GO:0019901	protein kinase binding

Biological Process

GO:0001519	peptide amidation
GO:0001666	response to hypoxia
GO:0001676	long-chain fatty acid metabolic process
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006518	peptide metabolic process
GO:0007417	central nervous system development
GO:0007507	heart development
GO:0007595	lactation
GO:0009268	response to pH
GO:0009404	toxin metabolic process
GO:0018032	protein amidation
GO:0022602	ovulation cycle process
GO:0032355	response to estradiol
GO:0032956	regulation of actin cytoskeleton organization
GO:0042476	odontogenesis
GO:0042493	response to drug
GO:0046688	response to copper ion
GO:0050708	regulation of protein secretion
GO:0051260	protein homooligomerization
GO:0051384	response to glucocorticoid
GO:0055114	oxidation-reduction process
GO:0060135	maternal process involved in female pregnancy
GO:0060173	limb development

Cellular Component

GO:0005615	extracellular space
GO:0005802	trans-Golgi network
GO:0005829	cytosol
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0030667	secretory granule membrane
GO:0043005	neuron projection
GO:0043204	perikaryon
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:97475

InterPro

IPR000323 Copper type II, ascorbate-dependent monooxygenase, N-terminal
IPR000720 Peptidyl-glycine alpha-amidating monooxygenase
IPR001258 NHL repeat
IPR008977 PHM/PNGase F domain
IPR013017 NHL repeat, subgroup

PFAM

PF01082
PF01436

PRINTS

PR00790

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite