InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dram2

Summary

InnateDB Protein

IDBP-184814.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dram2

Protein Name

VDNA-damage regulated autophagy modulator 2

Synonyms

2010305N14Rik; 2610318G18Rik; AI647667; Tmem77;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000063510

InnateDB Gene

IDBG-184812 (Dram2)

Protein Structure

UniProt Annotation

Function

Induces apoptotic cell death when coexpressed with DRAM1. {ECO:0000250}.

Subcellular Localization

Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0030262	apoptotic nuclear changes
GO:0097194	execution phase of apoptosis

Cellular Component

GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0015630	microtubule cytoskeleton
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:1914421

InterPro

IPR019402 Frag1/DRAM/Sfk1

PFAM

PF10277

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CR48

PhosphoSite

PhosphoSite-

TrEMBL

D3Z6B7

UniProt Splice Variant

Entrez Gene

67171

UniGene

Mm.472019

RefSeq

NP_080289

MGI ID

MGI Symbol

Dram2

OMIM

CCDS

CCDS17725

HPRD

IMGT

EMBL

AC117200 AK009940 AK012044 AK015888 AK052824 AK172455

GenPept

BAB26598 BAB27990 BAB30020 BAC35162 BAE43014