InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trit1

Summary

InnateDB Protein

IDBP-184824.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trit1

Protein Name

tRNA isopentenyltransferase 1

Synonyms

2310075G14Rik; AI314189; AI314635; AV099619; IPT; MOD5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099709

InnateDB Gene

IDBG-184822 (Trit1)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). {ECO:0000250}.

Subcellular Localization

Isoform 1: Mitochondrion {ECO:0000305}.Isoform 2: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004161	dimethylallyltranstransferase activity
GO:0005524	ATP binding
GO:0046872	metal ion binding
GO:0052381	tRNA dimethylallyltransferase activity

Biological Process

GO:0008033	tRNA processing
GO:0009058	biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:1914216

InterPro

IPR002627 tRNA isopentenyltransferase
IPR002648 Isopentenyl transferase
IPR018022 tRNA delta(2)-isopentenylpyrophosphate transferase
IPR022755 Zinc finger, double-stranded RNA binding
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01715
PF01745
PF12171

PRINTS

PIRSF

PIRSF000507

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80UN9