InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bmp8b

Summary

InnateDB Protein

IDBP-184872.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bmp8b

Protein Name

bone morphogenetic protein 8b

Synonyms

Op3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002457

InnateDB Gene

IDBG-184870 (Bmp8b)

Protein Structure

UniProt Annotation

Function

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Involved in the generation of primordial germ cells; this function involves Bmp4 in a synergistic manner though separate receptor complexes seem to be involved. Required for the initiation and maintenance of spermatogenesis. Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT. {ECO:0000250, ECO:0000269PubMed:10894154, ECO:0000269PubMed:11427739, ECO:0000269PubMed:22579288, ECO:0000269PubMed:8682296}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in testis. Expressed in decidual cells of the uterus and in trophoblast cells of the labyrinthine region of the placenta and in the inner root sheath of hair follicles of early postnatal skin. Expressed in the extraembryonic ectoderm in pregastrula and gastrula stage mouse embryos. Expressed in brown adipose tissue and brain. {ECO:0000269PubMed:10894154, ECO:0000269PubMed:22579288}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0008083	growth factor activity

Biological Process

GO:0001503	ossification
GO:0002024	diet induced thermogenesis
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007281	germ cell development
GO:0007283	spermatogenesis
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0040007	growth
GO:0043408	regulation of MAPK cascade
GO:0048598	embryonic morphogenesis
GO:0051216	cartilage development
GO:2000505	regulation of energy homeostasis