InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abcc6

Summary

InnateDB Protein

IDBP-184895.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcc6

Protein Name

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

Synonyms

Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002850

InnateDB Gene

IDBG-184893 (Abcc6)

Protein Structure

UniProt Annotation

Function

May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. {ECO:0000250}.

Subcellular Localization

Basolateral cell membrane {ECO:0000269PubMed:23625951}; Multi-pass membrane protein {ECO:0000255PROSITE-ProRule:PRU00441, ECO:0000269PubMed:23625951}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0055085	transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane

Protein Structure and Domains

PDB ID

MGI:1351634

InterPro

IPR001140 ABC transporter, transmembrane domain
IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00664
PF13748
PF00005

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9R1S7