InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppie

Summary

InnateDB Protein

IDBP-184922.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppie

Protein Name

peptidylprolyl isomerase E (cyclophilin E)

Synonyms

2010010D16Rik; Cyp33;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030404

InnateDB Gene

IDBG-184920 (Ppie)

Protein Structure

UniProt Annotation

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in pre-mRNA splicing (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0006457	protein folding
GO:0008380	RNA splicing
GO:0045070	positive regulation of viral genome replication

Cellular Component

GO:0005634	nucleus
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

MGI:1917118

InterPro

IPR000504 RNA recognition motif domain
IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
IPR016304 Cyclophilin-type peptidyl-prolyl cis-trans isomerase E
IPR029000 Cyclophilin-like domain

PFAM

PF00076
PF00160

PRINTS

PR00153

PIRSF

PIRSF001475

SMART

SM00360

TIGRFAMs

Post-translational Modifications

Modification

Cross-References