Mus musculus Protein: Ppie
Summary
InnateDB Protein IDBP-184922.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppie
Protein Name peptidylprolyl isomerase E (cyclophilin E)
Synonyms 2010010D16Rik; Cyp33;
Species Mus musculus
Ensembl Protein ENSMUSP00000030404
InnateDB Gene IDBG-184920 (Ppie)
Protein Structure
UniProt Annotation
Function PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in pre-mRNA splicing (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006355 regulation of transcription, DNA-templated
GO:0006397 mRNA processing
GO:0006457 protein folding
GO:0008380 RNA splicing
GO:0045070 positive regulation of viral genome replication
Cellular Component
GO:0005634 nucleus
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID MGI:1917118
InterPro IPR000504 RNA recognition motif domain
IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
IPR016304 Cyclophilin-type peptidyl-prolyl cis-trans isomerase E
IPR029000 Cyclophilin-like domain
PFAM PF00076
PF00160
PRINTS PR00153
PIRSF PIRSF001475
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QZH3
PhosphoSite PhosphoSite-Q9QZH3
TrEMBL
UniProt Splice Variant
Entrez Gene 56031
UniGene
RefSeq NP_062362
MGI ID
MGI Symbol Ppie
OMIM
CCDS CCDS18610
HPRD
IMGT
EMBL AF182825 AK008177 BC045154
GenPept AAF01030 AAH45154 BAB25512