Version 5.4
Mus musculus Protein: Nt5c1a
Summary
InnateDB Protein IDBP-185005.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nt5c1a
Protein Name 5'-nucleotidase, cytosolic IA
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000069422
InnateDB Gene IDBG-185003 (Nt5c1a)
Protein Structure
UniProt Annotation
Function Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0008253 5'-nucleotidase activity
Biological Process
GO:0009117 nucleotide metabolic process
GO:0009128 purine nucleoside monophosphate catabolic process
GO:0016311 dephosphorylation
GO:0046085 adenosine metabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2155700
InterPro IPR010394 5-nucleotidase
PFAM PF06189
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A3KFX0
PhosphoSite PhosphoSite-A3KFX0
TrEMBL
UniProt Splice Variant
Entrez Gene 230718
UniGene Mm.354635
RefSeq NP_001078971
MGI ID
MGI Symbol Nt5c1a
OMIM
CCDS CCDS38871
HPRD
IMGT
EMBL AL606934 BC147308 BC147309 BC147730 BC147733 CH466552
GenPept AAI47309 AAI47310 AAI47731 AAI47734 EDL30387

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca