InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Heyl

Summary

InnateDB Protein

IDBP-185031.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Heyl

Protein Name

hairy/enhancer-of-split related with YRPW motif-like

Synonyms

bHLHb33; hesr3; Hey3; Hrt3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040576

InnateDB Gene

IDBG-185029 (Heyl)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. {ECO:0000250, ECO:0000269PubMed:16199874, ECO:0000269PubMed:17303760}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00380, ECO:0000255PROSITE-ProRule:PRU00981}.

Disease Associations

Tissue Specificity

Expressed in heart and at lower levels in brain, lung, muscle, ovary and testis. {ECO:0000269PubMed:10860664}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000983	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0000988	protein binding transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0035939	microsatellite binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0050683	AF-1 domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0003151	outflow tract morphogenesis
GO:0003181	atrioventricular valve morphogenesis
GO:0003184	pulmonary valve morphogenesis
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003203	endocardial cushion morphogenesis
GO:0003208	cardiac ventricle morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007219	Notch signaling pathway
GO:0007422	peripheral nervous system development
GO:0010629	negative regulation of gene expression
GO:0014031	mesenchymal cell development
GO:0032835	glomerulus development
GO:0035914	skeletal muscle cell differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060317	cardiac epithelial to mesenchymal transition
GO:0060412	ventricular septum morphogenesis
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:0071773	cellular response to BMP stimulus
GO:0072014	proximal tubule development
GO:2000824	negative regulation of androgen receptor activity