InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdc5l

Summary

InnateDB Protein

IDBP-185060.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdc5l

Protein Name

cell division cycle 5-like (S. pombe)

Synonyms

1200002I02Rik; AA408004; PCDC5RP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024727

InnateDB Gene

IDBG-185058 (Cdc5l)

Protein Structure

UniProt Annotation

Function

DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00625, ECO:0000269PubMed:10570151}. Nucleus speckle {ECO:0000255PROSITE-ProRule:PRU00625}. Cytoplasm {ECO:0000250}. Note=May shuttle between cytoplasm and nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 136 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	136 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0044822	poly(A) RNA binding
GO:0071987	WD40-repeat domain binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0008380	RNA splicing

Cellular Component

GO:0000974	Prp19 complex
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016607	nuclear speck
GO:0071013	catalytic step 2 spliceosome