InnateDB Protein
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IDBP-185099.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Med19
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Protein Name
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mediator of RNA polymerase II transcription, subunit 19 homolog (yeast)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000099705
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InnateDB Gene
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IDBG-185097 (Med19)
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Protein Structure
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Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
13
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
58 [view]
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Molecular Function |
Accession |
GO Term |
GO:0001104
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RNA polymerase II transcription cofactor activity
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GO:0005515
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protein binding
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Biological Process |
GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0008150
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biological_process
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Cellular Component |
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PDB ID |
MGI:1914234
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InterPro |
IPR019403
Mediator complex, subunit Med19, metazoa
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PFAM |
PF10278
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8C1S0
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PhosphoSite |
PhosphoSite-Q8C1S0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
381379
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UniGene |
Mm.219643
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RefSeq |
NP_080161
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MGI ID |
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MGI Symbol |
Med19
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OMIM |
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CCDS |
CCDS16189
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HPRD |
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IMGT |
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EMBL |
AK005399
AK160579
AK168787
BC025475
BC044207
BC082559
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GenPept |
AAH25475
AAH44207
AAH82559
BAC25114
BAE35886
BAE40621
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