InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trpv2

Summary

InnateDB Protein

IDBP-185111.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trpv2

Protein Name

transient receptor potential cation channel, subfamily V, member 2

Synonyms

GRC; OTRPC2; VRL-1; Vrl1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099703

InnateDB Gene

IDBG-185105 (Trpv2)

Protein Structure

UniProt Annotation

Function

Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. {ECO:0000269PubMed:10559903, ECO:0000269PubMed:11707512}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cytoplasm. Melanosome {ECO:0000250}. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation.

Disease Associations

Tissue Specificity

Abundantly expressed in spleen, placenta, skeleton muscle, lung and brain. {ECO:0000269PubMed:10559903}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0009266	response to temperature stimulus
GO:0009408	response to heat
GO:0045773	positive regulation of axon extension
GO:0070588	calcium ion transmembrane transport
GO:0090280	positive regulation of calcium ion import

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0012505	endomembrane system
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0032584	growth cone membrane
GO:0042470	melanosome
GO:0044295	axonal growth cone
GO:0044297	cell body

Protein Structure and Domains

PDB ID

MGI:1341836

InterPro

IPR002110 Ankyrin repeat
IPR004729 Transient receptor potential channel
IPR008347 Transient receptor potential channel, vanilloid 1-4
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00023
PF13606
PF11929
PF12796

PRINTS

PR01415
PR01768

PIRSF

SMART

SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt