Version 5.4
Mus musculus Protein: Prok1
Summary
InnateDB Protein IDBP-185131.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prok1
Protein Name prokineticin 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000060617
InnateDB Gene IDBG-185129 (Prok1)
Protein Structure
UniProt Annotation
Function Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis. {ECO:0000250UniProtKB:P58294, ECO:0000269PubMed:12746324, ECO:0000269PubMed:17324478, ECO:0000269PubMed:17531315}.
Subcellular Localization Secreted {ECO:0000250UniProtKB:P58294}.
Disease Associations
Tissue Specificity Highly expressed in liver and ovary and weakly expressed in testis and placenta. Expressed in mucosa and mesenchyme of embryonic gut during enteric nervous system development (at protein level). Predominantly expressed in kidney and liver. Also expressed in lung, ovary, placenta and testis. In fetal liver, is restricted to and highly expressed in hepatocytes. In adult kidney, expression is restricted to the endothelial tubule cells. In placenta, expressed throughout gestation. {ECO:0000269PubMed:12746324, ECO:0000269PubMed:17324478, ECO:0000269PubMed:17531315}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell proliferation
GO:0045765 regulation of angiogenesis
GO:0051781 positive regulation of cell division
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:2180370
InterPro IPR023569 Prokineticin domain
PFAM PF06607
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14A28
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 246691
UniGene
RefSeq NP_001037847
MGI ID
MGI Symbol Prok1
OMIM
CCDS CCDS38589
HPRD
IMGT
EMBL AF487281 BC042707 BC117006 BC117008 CH466607
GenPept AAH42707 AAI17007 AAI17009 AAM49573 EDL01898

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca