Version 5.4
Mus musculus Protein: Aars2
Summary
InnateDB Protein IDBP-185237.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aars2
Protein Name alanyl-tRNA synthetase 2, mitochondrial (putative)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000024733
InnateDB Gene IDBG-185235 (Aars2)
Protein Structure
UniProt Annotation
Function Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. {ECO:0000255HAMAP-Rule:MF_03133}.
Subcellular Localization Mitochondrion.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004813 alanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds
GO:0046872 metal ion binding
Biological Process
GO:0006419 alanyl-tRNA aminoacylation
GO:0033108 mitochondrial respiratory chain complex assembly
GO:0043039 tRNA aminoacylation
GO:0070143 mitochondrial alanyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:2681839
InterPro IPR002318 Alanine-tRNA ligase, class IIc
IPR012947 Threonyl/alanyl tRNA synthetase, SAD
IPR018162 Alanine-tRNA ligase, class IIc, anti-codon-binding domain
IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain
IPR018164 Alanyl-tRNA synthetase, class IIc, N-terminal
IPR018165 Alanyl-tRNA synthetase, class IIc, core domain
PFAM PF07973
PF01411
PRINTS PR00980
PIRSF
SMART SM00863
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14CH7
PhosphoSite PhosphoSite-Q14CH7
TrEMBL
UniProt Splice Variant
Entrez Gene 224805
UniGene Mm.329063
RefSeq NP_941010
MGI ID
MGI Symbol Aars2
OMIM
CCDS CCDS28809
HPRD
IMGT
EMBL AK173139 BC079844 BC113172 BC113779
GenPept AAH79844 AAI13173 AAI13780 BAD32417

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca