InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abcc8

Summary

InnateDB Protein

IDBP-185240.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Abcc8

Protein Name

ATP-binding cassette, sub-family C (CFTR/MRP), member 8

Synonyms

D930031B21Rik; Sur; SUR1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033123

InnateDB Gene

IDBG-185238 (Abcc8)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0008281	sulfonylurea receptor activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances
GO:0044325	ion channel binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0006813	potassium ion transport
GO:0007165	signal transduction
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1352629

InterPro

IPR000388 Sulphonylurea receptor
IPR000844 Sulphonylurea receptor, type 1
IPR001140 ABC transporter, transmembrane domain
IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00664
PF13748
PF00005

PRINTS

PR01092
PR01093

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt