Version 5.4
Mus musculus Protein: Tmod3
Summary
InnateDB Protein IDBP-185260.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmod3
Protein Name tropomodulin 3
Synonyms U-Tmod; UTMOD;
Species Mus musculus
Ensembl Protein ENSMUSP00000072087
InnateDB Gene IDBG-185258 (Tmod3)
Protein Structure
UniProt Annotation
Function Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005523 tropomyosin binding
Biological Process
Cellular Component
GO:0005856 cytoskeleton
GO:0005865 striated muscle thin filament
Protein Structure and Domains
PDB ID MGI:1355315
InterPro IPR004934 Tropomodulin
PFAM PF03250
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JHJ0
PhosphoSite PhosphoSite-Q9JHJ0
TrEMBL Q8C3Z3
UniProt Splice Variant
Entrez Gene 50875
UniGene Mm.413304
RefSeq NP_058659
MGI ID
MGI Symbol Tmod3
OMIM
CCDS CCDS23344
HPRD
IMGT
EMBL AF177172 AF237630 AK050372 AK084463 AK167723 BC082595
GenPept AAF31671 AAF45298 AAH82595 BAC34216 BAC39191 BAE39765

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca