InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Serping1

Summary

InnateDB Protein

IDBP-185266.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Serping1

Protein Name

serine (or cysteine) peptidase inhibitor, clade G, member 1

Synonyms

C1INH; C1nh;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023994

InnateDB Gene

IDBG-185264 (Serping1)

Protein Structure

UniProt Annotation

Function

Activation of the C1 complex is under control of the C1- inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. May inhibit chymotrypsin and kallikrein.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0001869	negative regulation of complement activation, lectin pathway
GO:0006958	complement activation, classical pathway
GO:0007568	aging
GO:0007596	blood coagulation
GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis
GO:0030193	regulation of blood coagulation
GO:0042730	fibrinolysis
GO:0045087	innate immune response