InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bmp8a

Summary

InnateDB Protein

IDBP-185386.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bmp8a

Protein Name

bone morphogenetic protein 8a

Synonyms

Bmp7r1; OP-2; OP2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099701

InnateDB Gene

IDBG-185384 (Bmp8a)

Protein Structure

UniProt Annotation

Function

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Has only marginal osteoinductive activity in mesenchymal progenitor and osteoprogenior cells but shows activity in committed osteoblastic cells. {ECO:0000250, ECO:0000269PubMed:12925636}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in testis. expressed in trophoblast cells of the labyrinthine region of the placenta and in the inner root sheath of hair follicles of early postnatal skin. {ECO:0000269PubMed:8843393}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0008083	growth factor activity

Biological Process

GO:0001649	osteoblast differentiation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007281	germ cell development
GO:0007283	spermatogenesis
GO:0040007	growth
GO:0051216	cartilage development