Version 5.4
Mus musculus Protein: Nfkbie
Summary
InnateDB Protein IDBP-185409.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nfkbie
Protein Name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
Synonyms IKBE;
Species Mus musculus
Ensembl Protein ENSMUSP00000024742
InnateDB Gene IDBG-185407 (Nfkbie)
Protein Structure
UniProt Annotation
Function Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 51 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0042942 D-serine transport
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005794 Golgi apparatus
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:1194908
InterPro IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O54910
PhosphoSite PhosphoSite-O54910
TrEMBL
UniProt Splice Variant
Entrez Gene 18037
UniGene Mm.57043
RefSeq NP_032716
MGI ID
MGI Symbol Nfkbie
OMIM
CCDS CCDS28811
HPRD
IMGT
EMBL AF030896 AK008843 AK011965 AK151450 AK153248 BC030923
GenPept AAB97517 AAH30923 BAB25924 BAB27943 BAE30410 BAE31839

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca