InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dync1li2

Summary

InnateDB Protein

IDBP-185441.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dync1li2

Protein Name

dynein, cytoplasmic 1 light intermediate chain 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045480

InnateDB Gene

IDBG-185439 (Dync1li2)

Protein Structure

UniProt Annotation

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0006810	transport
GO:0007018	microtubule-based movement
GO:0008152	metabolic process
GO:0051642	centrosome localization