InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rimklb

Summary

InnateDB Protein

IDBP-185457.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rimklb

Protein Name

ribosomal modification protein rimK-like family member B

Synonyms

4931417E21Rik; 4933426K21Rik; AA097693; AI325948; AU015629; Naags;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064467

InnateDB Gene

IDBG-185453 (Rimklb)

Protein Structure

UniProt Annotation

Function

Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate. {ECO:0000269PubMed:20643647, ECO:0000269PubMed:20657015}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:20643647}.

Disease Associations

Tissue Specificity

Strongly expressed in brain and testis. Expressed in eyes, thymus, lung, kidney, skeletal muscle, spleen, skin and heart. Expressed in neurons of the neocortex, the gray matter and Purkinje cells. {ECO:0000269PubMed:20643647}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004363	glutathione synthase activity
GO:0005524	ATP binding
GO:0046872	metal ion binding
GO:0072590	N-acetyl-L-aspartate-L-glutamate ligase activity
GO:0072591	citrate-L-glutamate ligase activity

Biological Process

GO:0006464	cellular protein modification process
GO:0006750	glutathione biosynthetic process

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1918325

InterPro

IPR003806 ATP-grasp fold, DUF201-type
IPR004218 Prokaryotic glutathione synthetase, ATP-binding
IPR004666 Ribosomal S6 modification enzyme RimK/Lysine biosynthesis enzyme LysX
IPR011761 ATP-grasp fold
IPR013651 ATP-grasp fold, RimK-type

PFAM

PF02655
PF02955
PF08443

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80WS1

PhosphoSite