InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spp1

Summary

InnateDB Protein

IDBP-185489.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spp1

Protein Name

secreted phosphoprotein 1

Synonyms

2AR; Apl-1; BNSP; Bsp; BSPI; Eta; ETA-1; OP; Opn; Opnl; Ric; Spp-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031243

InnateDB Gene

IDBG-185485 (Spp1)

Protein Structure

UniProt Annotation

Function

Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 76 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	3 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	76 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0050840	extracellular matrix binding

Biological Process

GO:0001503	ossification
GO:0007155	cell adhesion
GO:0010811	positive regulation of cell-substrate adhesion
GO:0030593	neutrophil chemotaxis
GO:0031214	biomineral tissue development
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)