Version 5.4
Mus musculus Protein: Hmgcll1
Summary
InnateDB Protein IDBP-185606.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hmgcll1
Protein Name 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000008052
InnateDB Gene IDBG-185604 (Hmgcll1)
Protein Structure
UniProt Annotation
Function Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy- 3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004419 hydroxymethylglutaryl-CoA lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0046951 ketone body biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:2446108
InterPro IPR000891 Pyruvate carboxyltransferase
PFAM PF00682
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8JZS7
PhosphoSite PhosphoSite-Q8JZS7
TrEMBL
UniProt Splice Variant
Entrez Gene 208982
UniGene Mm.82306
RefSeq NP_776092
MGI ID
MGI Symbol Hmgcll1
OMIM
CCDS CCDS23349
HPRD
IMGT
EMBL AK141622 BC037381
GenPept AAH37381 BAE24772

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca