InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nae1

Summary

InnateDB Protein

IDBP-185612.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nae1

Protein Name

NEDD8 activating enzyme E1 subunit 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034349

InnateDB Gene

IDBG-185610 (Nae1)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}. Note=Colocalizes with APP in lipid rafts. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0019781	NEDD8 activating enzyme activity
GO:0031625	ubiquitin protein ligase binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0033314	mitotic DNA replication checkpoint
GO:0042981	regulation of apoptotic process
GO:0043523	regulation of neuron apoptotic process
GO:0045116	protein neddylation
GO:0051402	neuron apoptotic process