InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Phlpp1

Summary

InnateDB Protein

IDBP-185615.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Phlpp1

Protein Name

PH domain and leucine rich repeat protein phosphatase 1

Synonyms

AI836256; mKIAA0606; Phlpp; Plekhe1; SCOP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000056530

InnateDB Gene

IDBG-185613 (Phlpp1)

Protein Structure

UniProt Annotation

Function

Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB, and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004721	phosphoprotein phosphatase activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0009649	entrainment of circadian clock
GO:0016311	dephosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:2138327

InterPro

IPR001611 Leucine-rich repeat
IPR001849 Pleckstrin homology domain
IPR001932 Protein phosphatase 2C (PP2C)-like domain
IPR003591 Leucine-rich repeat, typical subtype

PFAM

PF00560
PF13504
PF13855
PF00169
PF00481
PF07228

PRINTS

PIRSF

SMART

SM00233
SM00331
SM00332
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CHE4