Version 5.4
Mus musculus Protein: Hs3st3b1
Summary
InnateDB Protein IDBP-185664.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hs3st3b1
Protein Name heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
Synonyms 3-OST-3B; 3Ost3b; 3OST3B1; AU041882; AW536289; Hs3st3b; m3-OST-3B;
Species Mus musculus
Ensembl Protein ENSMUSP00000091647
InnateDB Gene IDBG-185662 (Hs3st3b1)
Protein Structure
UniProt Annotation
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000305PubMed:10520990}; Single-pass type II membrane protein {ECO:0000305PubMed:10520990}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008146 sulfotransferase activity
GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
GO:0033872 [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity
Biological Process
GO:0006477 protein sulfation
Cellular Component
GO:0000139 Golgi membrane
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID MGI:1333853
InterPro IPR000863 Sulfotransferase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00685
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QZS6
PhosphoSite PhosphoSite-Q9QZS6
TrEMBL
UniProt Splice Variant
Entrez Gene 54710
UniGene Mm.403168
RefSeq NP_061275
MGI ID
MGI Symbol Hs3st3b1
OMIM
CCDS CCDS24838
HPRD
IMGT
EMBL AF168992 AL603889 CH466601
GenPept AAF04505 CAI35924 EDL10388

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca