InnateDB Protein
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IDBP-185669.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dppa3
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Protein Name
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developmental pluripotency-associated 3
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Synonyms
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2410075G02Rik; PCG7; PGC7; Stella;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000062832
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InnateDB Gene
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IDBG-185667 (Dppa3)
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Protein Structure
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Function |
Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis. {ECO:0000269PubMed:12124616, ECO:0000269PubMed:12620990, ECO:0000269PubMed:14654002, ECO:0000269PubMed:17143267, ECO:0000269PubMed:21407207, ECO:0000269PubMed:22034526, ECO:0000269PubMed:22722204}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=Localized in the cytoplasm at the primary oocyte stage and in oocytes within mono- laminar follicles. Expressed in the nucleus and cytoplasm of oocytes in bi-laminar and Graafian follicles and during the 2-cell and morula stages. In E3.5 blastocysts localization is mainly nuclear. Mainly localizes in the female pronucleus, localization to the male pronucleus in much weaker.
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Disease Associations |
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Tissue Specificity |
Expressed in the immature oocytes and in newborn ovaries. Subsequently detected in maturing oocytes and in preimplantation embryos. Expressed in pluripotent embryonic but not in differentiated somatic cells. Expressed in blastocysts, epiblasts, primordial germ cells, embryonic gonads and primitive spermatogonia. No expression is detected in adult testes. {ECO:0000269PubMed:11900980, ECO:0000269PubMed:12124616, ECO:0000269PubMed:12620990}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
0
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1920958
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8QZY3
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PhosphoSite |
PhosphoSite-Q8QZY3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
73708
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UniGene |
Mm.27982
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RefSeq |
NP_631964
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MGI ID |
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MGI Symbol |
Dppa3
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OMIM |
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CCDS |
CCDS20500
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HPRD |
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IMGT |
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EMBL |
AB072734
AC158651
AF490347
AK135769
AK136263
AY082485
AY134859
BC099433
BC100331
BC107340
BC107341
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GenPept |
AAH99433
AAI00332
AAI07341
AAI07342
AAM03317
AAN12283
AAO84505
BAB86304
BAE22650
BAE22904
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