Version 5.4
Mus musculus Protein: Cox10
Summary
InnateDB Protein IDBP-185693.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cox10
Protein Name COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)
Synonyms 2410004F01Rik; AU042636;
Species Mus musculus
Ensembl Protein ENSMUSP00000040138
InnateDB Gene IDBG-185691 (Cox10)
Protein Structure
UniProt Annotation
Function Converts protoheme IX and farnesyl diphosphate to heme O. {ECO:0000250}.
Subcellular Localization Mitochondrion membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004129 cytochrome-c oxidase activity
GO:0004659 prenyltransferase activity
GO:0008495 protoheme IX farnesyltransferase activity
Biological Process
GO:0000266 mitochondrial fission
GO:0006783 heme biosynthetic process
GO:0006784 heme a biosynthetic process
GO:0007005 mitochondrion organization
GO:0008535 respiratory chain complex IV assembly
GO:0009060 aerobic respiration
GO:0017004 cytochrome complex assembly
GO:0045333 cellular respiration
GO:0048034 heme O biosynthetic process
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Protein Structure and Domains
PDB ID MGI:1917633
InterPro IPR000537 UbiA prenyltransferase family
IPR006369 Protohaem IX farnesyltransferase
IPR016315 Protohaem IX farnesyltransferase, mitochondria
PFAM PF01040
PRINTS
PIRSF PIRSF001773
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CFY5
PhosphoSite PhosphoSite-
TrEMBL Q3UDN4
UniProt Splice Variant
Entrez Gene 70383
UniGene Mm.340211
RefSeq NP_848466
MGI ID
MGI Symbol Cox10
OMIM
CCDS CCDS24839
HPRD
IMGT
EMBL AK149999 AK154668 AL603889 AL663033 BC038046 CH466601
GenPept AAH38046 BAE29227 BAE32754 CAI25610 CAI26029 EDL10389

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca