InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hcrtr2

Summary

InnateDB Protein

IDBP-185705.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hcrtr2

Protein Name

hypocretin (orexin) receptor 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058230

InnateDB Gene

IDBG-185703 (Hcrtr2)

Protein Structure

UniProt Annotation

Function

Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Widely expressed. Isoform 2 not detected in skeletal muscle and kidney. {ECO:0000269PubMed:15256537}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0016499	orexin receptor activity
GO:0017046	peptide hormone binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007631	feeding behavior
GO:0022410	circadian sleep/wake cycle process

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2680765

InterPro

IPR000204 Orexin receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR004060 Orexin receptor 2
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF03827
PF10320

PRINTS

PR01064
PR00237
PR01012
PR01522

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P58308