InnateDB Protein
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IDBP-185743.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Hs3st3a1
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Protein Name
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heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
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Synonyms
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3Ost3a; Hs3st3a;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000055930
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InnateDB Gene
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IDBG-185741 (Hs3st3a1)
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Protein Structure
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Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). {ECO:0000250}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0003674
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molecular_function
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GO:0008146
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sulfotransferase activity
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GO:0008467
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[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1333861
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InterPro |
IPR000863
Sulfotransferase domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00685
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BKN6
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PhosphoSite |
PhosphoSite-Q8BKN6
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TrEMBL |
Q52KJ0
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UniProt Splice Variant |
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Entrez Gene |
15478
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UniGene |
Mm.340214
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RefSeq |
NP_849201
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MGI ID |
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MGI Symbol |
Hs3st3a1
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OMIM |
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CCDS |
CCDS24840
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HPRD |
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IMGT |
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EMBL |
AK051284
AL646051
AL672141
BC094320
CH466601
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GenPept |
AAH94320
BAC34592
CAI24606
CAI24639
EDL10396
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