InnateDB Protein
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IDBP-185814.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Elk3
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Protein Name
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ELK3, member of ETS oncogene family
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Synonyms
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D430049E23Rik; Erp; Etrp; Net; Sap-2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000008542
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InnateDB Gene
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IDBG-185812 (Elk3)
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Protein Structure
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Function |
May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Heart, liver, lung, kidney and muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0000981
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sequence-specific DNA binding RNA polymerase II transcription factor activity
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GO:0001077
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0003714
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transcription corepressor activity
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GO:0005515
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protein binding
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GO:0032422
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purine-rich negative regulatory element binding
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
GO:0001525
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angiogenesis
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0030154
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cell differentiation
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GO:0042060
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wound healing
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
MGI:101762
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InterPro |
IPR000418
Ets domain
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PFAM |
PF00178
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PRINTS |
PR00454
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PIRSF |
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SMART |
SM00413
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TIGRFAMs |
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Modification |
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SwissProt |
P41971
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PhosphoSite |
PhosphoSite-P41971
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TrEMBL |
A9L8S9
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UniProt Splice Variant |
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Entrez Gene |
13713
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UniGene |
Mm.472341
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RefSeq |
NP_038536
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MGI ID |
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MGI Symbol |
Elk3
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OMIM |
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CCDS |
CCDS24124
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HPRD |
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IMGT |
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EMBL |
AK052546
D26065
L19953
S82864
Z32815
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GenPept |
AAA19872
AAB46893
BAC35034
BAF93848
CAA83676
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