InnateDB Protein
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IDBP-185843.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Foxj2
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Protein Name
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forkhead box J2
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Synonyms
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Fhx;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000003238
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InnateDB Gene
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IDBG-185841 (Foxj2)
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Protein Structure
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Function |
Transcriptional activator. Able to bind to two different type of DNA binding sites. {ECO:0000269PubMed:11025217}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
In embryos, both cell layers of the blastocyst: the trophectoderm (TE) and the inner cell mass (ICM) show expression. Expressed in adult brain, heart skeletal muscle, lung, kidney and gonads. Liver, small intestine, and spleen also show expression but at lower levels. In the testis, expressed from pachytene spermatocytes to round spermatids, but not in spermatogonia. In addition to the germ lineage, also expressed in Sertoli cells of the testis. In the ovary, only granulosa cells of the follicles show expression. In the brain, expressed in the piriform cortex, hippocampus, habenula and in the granula cell layer in the cerebellum. {ECO:0000269PubMed:11025217, ECO:0000269PubMed:16376864}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0001077
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0008301
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DNA binding, bending
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0007389
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pattern specification process
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GO:0009888
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tissue development
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
MGI:1926805
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InterPro |
IPR001766
Transcription factor, fork head
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PFAM |
PF00250
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PRINTS |
PR00053
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PIRSF |
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SMART |
SM00339
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TIGRFAMs |
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Modification |
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SwissProt |
Q9ES18
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PhosphoSite |
PhosphoSite-Q9ES18
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TrEMBL |
Q3U3U9
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UniProt Splice Variant |
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Entrez Gene |
60611
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UniGene |
Mm.87142
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RefSeq |
NP_068699
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MGI ID |
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MGI Symbol |
Foxj2
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OMIM |
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CCDS |
CCDS20503
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HPRD |
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IMGT |
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EMBL |
AF253052
AK154574
BC040395
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GenPept |
AAG30406
AAH40395
BAE32686
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