InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lta4h

Summary

InnateDB Protein

IDBP-185865.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lta4h

Protein Name

leukotriene A4 hydrolase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000016033

InnateDB Gene

IDBG-185863 (Lta4h)

Protein Structure

UniProt Annotation

Function

Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. {ECO:0000269PubMed:9287304}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0004301	epoxide hydrolase activity
GO:0004463	leukotriene-A4 hydrolase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006508	proteolysis
GO:0019370	leukotriene biosynthetic process
GO:0043171	peptide catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:96836

InterPro

IPR012777 Leukotriene A4 hydrolase
IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal
IPR015211 Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal
IPR016024 Armadillo-type fold

PFAM

PF01433
PF09127

PRINTS

PR00756

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P24527