Version 5.4
Mus musculus Protein: C3ar1
Summary
InnateDB Protein IDBP-185908.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C3ar1
Protein Name complement component 3a receptor 1
Synonyms AZ3B; C3AR; HNFAG09;
Species Mus musculus
Ensembl Protein ENSMUSP00000048092
InnateDB Gene IDBG-185906 (C3ar1)
Protein Structure
UniProt Annotation
Function Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Detected in varying levels in all tissues examined except the spleen. Especially abundant in heart and lung.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004943 C3a anaphylatoxin receptor activity
Biological Process
GO:0006935 chemotaxis
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0010759 positive regulation of macrophage chemotaxis
GO:0045087 innate immune response (InnateDB)
GO:0045766 positive regulation of angiogenesis
GO:0090023 positive regulation of neutrophil chemotaxis
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1097680
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001274 C5a1/C5a2 anaphylatoxin chemotactic receptor
IPR001644 C3a anaphylatoxin chemotactic receptor
IPR002234 Anaphylatoxin chemotactic receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
PFAM PF00001
PF10320
PRINTS PR00237
PR00426
PR01060
PR01104
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O09047
PhosphoSite PhosphoSite-O09047
TrEMBL Q5U7A4
UniProt Splice Variant
Entrez Gene 12267
UniGene Mm.2408
RefSeq NP_033909
MGI ID
MGI Symbol C3ar1
OMIM
CCDS CCDS20504
HPRD
IMGT
EMBL AF053757 AK154134 AK154229 AK154609 AY786554 BC003728 CH466523 EU007909 U77460 U77461 U97537
GenPept AAB71814 AAC40193 AAC53203 AAC53204 AAH03728 AAV51803 ABV02577 BAE32398 BAE32449 BAE32711 EDK99698

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca