Version 5.4
Mus musculus Protein: Arhgap44
Summary
InnateDB Protein IDBP-186018.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgap44
Protein Name Rho GTPase activating protein 44
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000090680
InnateDB Gene IDBG-186008 (Arhgap44)
Protein Structure
UniProt Annotation
Function GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP- bound states. May act as a GAP for CDC42 and RAC1. Endosomal recycling protein which, in association with SHANK3, is involved in synaptic plasticity. Promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation. {ECO:0000269PubMed:23739967}.
Subcellular Localization Cell projection, dendritic spine {ECO:0000269PubMed:23739967}. Recycling endosome {ECO:0000269PubMed:23739967}. Cell junction, synapse {ECO:0000250}. Note=In CA1 hippocampal synapses, detected at both presynaptic and postsynaptic sites. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in hippocampal neurons (at protein level). {ECO:0000269PubMed:23739967}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
Biological Process
GO:0007165 signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0030054 cell junction
GO:0031256 leading edge membrane
GO:0043197 dendritic spine
GO:0045202 synapse
GO:0055037 recycling endosome
Protein Structure and Domains
PDB ID MGI:2144423
InterPro IPR004148 BAR domain
PFAM PF03114
PRINTS
PIRSF
SMART SM00721
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5SSM3
PhosphoSite PhosphoSite-Q5SSM3
TrEMBL
UniProt Splice Variant
Entrez Gene 216831
UniGene Mm.443643
RefSeq
MGI ID
MGI Symbol Arhgap44
OMIM
CCDS
HPRD
IMGT
EMBL AK053220 AL663045 BC056366 BC059911
GenPept AAH56366 AAH59911 BAC35316 CAI24613 CAI24614 CAI24616 CAI24617

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca