InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gpc6

Summary

InnateDB Protein

IDBP-186076.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpc6

Protein Name

glypican 6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000085835

InnateDB Gene

IDBG-186074 (Gpc6)

Protein Structure

UniProt Annotation

Function

Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Enhances migration and invasion of cancer cells through WNT5A signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.Secreted glypican-6: Secreted, extracellular space {ECO:0000250}.

Disease Associations

Tissue Specificity

In the cartilage growth-plate, gradient of expression with highest levels from the proliferative and pre- hypertrophic zones to lowest, if any, in the hypertrophic zones (at protein level). {ECO:0000269PubMed:19481194}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0043395	heparan sulfate proteoglycan binding

Biological Process

GO:0016477

cell migration

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005796	Golgi lumen
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0031225	anchored component of membrane