InnateDB Protein
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IDBP-186078.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Gpc6
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Protein Name
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glypican 6
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000077893
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InnateDB Gene
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IDBG-186074 (Gpc6)
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Protein Structure
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Function |
Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Enhances migration and invasion of cancer cells through WNT5A signaling (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.Secreted glypican-6: Secreted, extracellular space {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
In the cartilage growth-plate, gradient of expression with highest levels from the proliferative and pre- hypertrophic zones to lowest, if any, in the hypertrophic zones (at protein level). {ECO:0000269PubMed:19481194}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0043395
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heparan sulfate proteoglycan binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1346322
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InterPro |
IPR001863
Glypican
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PFAM |
PF01153
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9R087
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q3V1C9
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UniProt Splice Variant |
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Entrez Gene |
23888
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UniGene |
Mm.483065
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RefSeq |
NP_035951
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MGI ID |
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MGI Symbol |
Gpc6
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OMIM |
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CCDS |
CCDS27330
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HPRD |
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IMGT |
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EMBL |
AF105268
AK132531
CH466544
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GenPept |
AAD55750
BAE21222
EDL00556
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