Version 5.4
Mus musculus Protein: Lrrc8c
Summary
InnateDB Protein IDBP-186101.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lrrc8c
Protein Name leucine rich repeat containing 8 family, member C
Synonyms AD158; AI326115; E430036I04Rik; fad158;
Species Mus musculus
Ensembl Protein ENSMUSP00000066015
InnateDB Gene IDBG-186099 (Lrrc8c)
Protein Structure
UniProt Annotation
Function Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8C constitutes a pore-forming subunit or whether it is closely associated with the pore (By similarity). May play a role in adipogenesis. {ECO:0000250, ECO:0000269PubMed:15184384, ECO:0000269PubMed:15564382, ECO:0000269PubMed:21804215}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed at very low levels in adipose tissue. {ECO:0000269PubMed:15184384, ECO:0000269PubMed:15564382}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045444 fat cell differentiation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2140839
InterPro IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR021040 Leucine-rich repeat-containing protein 8, N-terminal
PFAM PF00560
PF13504
PF13855
PF12534
PRINTS
PIRSF
SMART SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R502
PhosphoSite PhosphoSite-Q8R502
TrEMBL Q3TNL3
UniProt Splice Variant
Entrez Gene 100604
UniGene Mm.411441
RefSeq NP_598658
MGI ID
MGI Symbol Lrrc8c
OMIM
CCDS CCDS19493
HPRD
IMGT
EMBL AB081508 AC122566 AC138265 AK089024 AK142337 AK165201 AK169492 BC025473 BC026572
GenPept AAH25473 AAH26572 BAB86302 BAC40706 BAE25036 BAE38075 BAE41199

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca