Version 5.4
Homo sapiens Protein: ACSM3
Summary
InnateDB Protein IDBP-18611.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACSM3
Protein Name acyl-CoA synthetase medium-chain family member 3
Synonyms SA; SAH;
Species Homo sapiens
Ensembl Protein ENSP00000289416
InnateDB Gene IDBG-18609 (ACSM3)
Protein Structure
UniProt Annotation
Function Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion matrix {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0015645 fatty acid ligase activity
GO:0046872 metal ion binding
GO:0047760 butyrate-CoA ligase activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0008152 metabolic process
GO:0008217 regulation of blood pressure
GO:0042632 cholesterol homeostasis
Cellular Component
GO:0005575 cellular_component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR000873 AMP-dependent synthetase/ligase
PFAM PF00501
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q53FZ2
PhosphoSite PhosphoSite-Q53FZ2
TrEMBL V9H1I0
UniProt Splice Variant
Entrez Gene 6296
UniGene Hs.706754
RefSeq NP_005613
HUGO HGNC:10522
OMIM 145505
CCDS CCDS10589
HPRD 07033
IMGT
EMBL AC004381 AC020926 AC141273 AK223139 BC002790 D16350 X80062 X80063 X80064
GenPept AAC31667 AAH02790 BAA03853 BAD96859 CAA56369 CAA56370 CAA56371

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca