InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OLR1

Summary

InnateDB Protein

IDBP-18614.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OLR1

Protein Name

oxidized low density lipoprotein (lectin-like) receptor 1

Synonyms

CLEC8A; LOX1; LOXIN; SCARE1; SLOX1;

Species

Homo sapiens

Ensembl Protein

ENSP00000309124

InnateDB Gene

IDBG-18612 (OLR1)

Protein Structure

UniProt Annotation

Function

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro- oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro- atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram- positive bacteria. {ECO:0000269PubMed:11821063, ECO:0000269PubMed:12354387, ECO:0000269PubMed:9052782}.

Subcellular Localization

Cell membrane; Lipid-anchor. Cell membrane; Single-pass type II membrane protein. Membrane raft. Secreted. Note=A secreted form also exists. Localization to membrane rafts requires palmitoylation.

Disease Associations

Note=Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction susceptibility.Note=OLR1 may be involved in Alzheimer disease (AD). Involvement in AD is however unclear: according to some authors (PubMed:12354387, PubMed:12810610 and PubMed:15976314), variations in OLR1 modify the risk of AD, while according to other (PubMed:15000751 and PubMed:15060104) they do not. {ECO:0000269PubMed:12384789, ECO:0000269PubMed:12807963, ECO:0000269PubMed:15860461}.

Tissue Specificity

Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level. {ECO:0000269PubMed:12354387, ECO:0000269PubMed:9052782, ECO:0000269PubMed:9828121}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005041	low-density lipoprotein receptor activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0006508	proteolysis
GO:0006898	receptor-mediated endocytosis
GO:0006954	inflammatory response
GO:0007159	leukocyte cell-cell adhesion
GO:0007596	blood coagulation
GO:0008015	blood circulation
GO:0008219	cell death
GO:0042157	lipoprotein metabolic process
GO:0042542	response to hydrogen peroxide
GO:0050900	leukocyte migration

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043235	receptor complex
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome