Mus musculus Protein: Fbxo9 | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-186196.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | Fbxo9 | ||||||||||
Protein Name | f-box protein 9 | ||||||||||
Synonyms | 9030401P18Rik; AA986398; | ||||||||||
Species | Mus musculus | ||||||||||
Ensembl Protein | ENSMUSP00000001402 | ||||||||||
InnateDB Gene | IDBG-186192 (Fbxo9) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity). {ECO:0000250}. | ||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. | ||||||||||
Disease Associations | |||||||||||
Tissue Specificity | |||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | MGI:1918788 | ||||||||||
InterPro |
IPR001810
F-box domain IPR007330 MIT |
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PFAM |
PF00646
PF12937 PF13013 PF04212 |
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PRINTS | |||||||||||
PIRSF | |||||||||||
SMART |
SM00256
SM00745 |
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TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | Q8BK06 | ||||||||||
PhosphoSite | PhosphoSite-Q8BK06 | ||||||||||
TrEMBL | |||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 71538 | ||||||||||
UniGene | Mm.28584 | ||||||||||
RefSeq | NP_001074959 | ||||||||||
MGI ID | |||||||||||
MGI Symbol | Fbxo9 | ||||||||||
OMIM | |||||||||||
CCDS | CCDS52864 | ||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | AB041585 AK018482 AK077607 BC020074 | ||||||||||
GenPept | AAH20074 BAA95068 BAB31231 BAC36897 | ||||||||||