Version 5.4
Mus musculus Protein: Ntn4
Summary
InnateDB Protein IDBP-186245.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ntn4
Protein Name netrin 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000020204
InnateDB Gene IDBG-186243 (Ntn4)
Protein Structure
UniProt Annotation
Function May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants. {ECO:0000269PubMed:11038171}.
Subcellular Localization Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
Disease Associations
Tissue Specificity Expressed in kidney, liver, heart, ovary, testis, retina, brain, olfactory bulb, and widely expressed in embryo. {ECO:0000269PubMed:10940631, ECO:0000269PubMed:11038171}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043237 laminin-1 binding
Biological Process
GO:0016322 neuron remodeling
GO:0060668 regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling
Cellular Component
GO:0005604 basement membrane
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:1888978
InterPro IPR001134 Netrin domain
IPR002049 EGF-like, laminin
IPR008211 Laminin, N-terminal
IPR008979 Galactose-binding domain-like
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR018933 Netrin module, non-TIMP type
PFAM PF00053
PF00055
PF01759
PRINTS
PIRSF
SMART SM00180
SM00136
SM00643
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JI33
PhosphoSite PhosphoSite-
TrEMBL D3Z053
UniProt Splice Variant
Entrez Gene 57764
UniGene Mm.483868
RefSeq NP_067295
MGI ID
MGI Symbol Ntn4
OMIM
CCDS CCDS24128
HPRD
IMGT
EMBL AC124585 AC151976 AF268066 AF281278
GenPept AAF91404 AAG30823

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca