InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Barhl2

Summary

InnateDB Protein

IDBP-186248.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Barhl2

Protein Name

BarH-like 2 (Drosophila)

Synonyms

E130309B19Rik; MBH1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000084005

InnateDB Gene

IDBG-186246 (Barhl2)

Protein Structure

UniProt Annotation

Function

Potential regulator of neural basic helix-loop-helix genes. It may down-regulate expression of ASCL1 and, within the thalamus, up-regulate NGN2, thereby regulating distinct patterns of neuronal differentiation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001709	cell fate determination
GO:0001764	neuron migration
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007399	nervous system development
GO:0030182	neuron differentiation
GO:0030516	regulation of axon extension
GO:0045165	cell fate commitment
GO:0045727	positive regulation of translation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter