Version 5.4
Mus musculus Protein: Ndufs5
Summary
InnateDB Protein IDBP-186253.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ndufs5
Protein Name NADH dehydrogenase (ubiquinone) Fe-S protein 5
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000030401
InnateDB Gene IDBG-186251 (Ndufs5)
Protein Structure
UniProt Annotation
Function Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Mitochondrion intermembrane space {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0070469 respiratory chain
Protein Structure and Domains
PDB ID MGI:1890889
InterPro IPR013892 Cytochrome c oxidase biogenesis protein Cmc1-like
IPR019342 NADH:ubiquinone oxidoreductase, iron-sulphur subunit 5
PFAM PF08583
PF10200
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99LY9
PhosphoSite PhosphoSite-Q99LY9
TrEMBL B1ARW4
UniProt Splice Variant
Entrez Gene 595136
UniGene
RefSeq NP_001025445
MGI ID
MGI Symbol Ndufs5
OMIM
CCDS CCDS18618
HPRD
IMGT
EMBL AK148505 AK152845 AL606932 BC081434 BX324169 CH466521 CH466552
GenPept AAH81434 BAE28590 BAE31538 CAM18556 EDK98017 EDL30376

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca