InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Serpinb11

Summary

InnateDB Protein

IDBP-186259.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Serpinb11

Protein Name

serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11

Synonyms

2310046M08Rik; AU015399;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027566

InnateDB Gene

IDBG-186257 (Serpinb11)

Protein Structure

UniProt Annotation

Function

Inhibitor of serine proteases. Has moderate inhibitory activity for trypsin-like peptidases, but also some activity with cysteine peptidases, cathepsin L, K, and V, and the serine peptidase, tryptase gamma. {ECO:0000269PubMed:17562709}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in eye, lung, lymphocytes, thymus, stomach, uterus, heart, brain, liver, skeletal muscle, and in day 7, 15, and 17 embryos. {ECO:0000269PubMed:17562709}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity

Biological Process

GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1914207

InterPro

IPR023796 Serpin domain

PFAM

PF00079

PRINTS

PIRSF

SMART

SM00093

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CQV3

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

66957

UniGene

Mm.12638

RefSeq

NP_080143

MGI ID

MGI Symbol

Serpinb11

OMIM

CCDS

CCDS15218

HPRD

IMGT

EMBL

AK009003 AK009855 AY367772 BC010313

GenPept

AAH10313 AAR89286 BAB26017 BAB26546